The Role of Heparin in Lipoprotein Metabolism.
نویسندگان
چکیده
Tecknical Papers A Possible Mechanism for the Nerve-blocking Action of n-AmylGCar resctell . 595 The Action of Peetinol and Pectin Esterase on Sections of Rat and Guinea Pig Stomachs: Perihan Cambel ............................. 596 The Preparation of Wet Ashed Tissues for Liquid Counting: Carl T. Bah#er,, D. B. Zilveremit, and Etta McDonald ...................... 597 Effect of Asorbic Acid on the Adrenal Weight of Normal and Hypophysectomized Rats: Louis-Paul Dugal and Mercedes Therien 598 The Interaction of Hyaluronidase with Thromboplastic Components of Blood Coagulation: Silvio Fiala, D. R. Meranze, and Karl Roth.. 600
منابع مشابه
Clearing factor, a heparin-activated lipoprotein lipase. I. Isolation and characterization of the enzyme from normal rat heart.
The importance of plasma lipoproteins in normal and abnormal fat metabolism has stimulated interest in the heparin-induced lipemia clearing system first observed by Hahn (2). As a result of the efforts of several independent investigators (3,4), it is now known that,, upon the administrat’ion of heparin to animals of many different species, an enzyme appears in the blood which is able to “clear...
متن کاملClearing Factor, a Heparin-activated Lipoprotein Lipase
In the first paper of this series (l), evidence was presented which demonstrates that the clearing factor which appears in postheparin plasma is present in the hearts of normal, non-heparinized rats. This strongly supports the view that the enzyme functions in normal fat metabolism. In this paper, the substrate specificity of lipoprotein lipase is defined, the conversion of coconut oil into an ...
متن کاملDisturbances of lipid metabolism in pancreatic disorders with special reference to serum lipoprotein lipase activity.
In order to clarify the mechanism of hyperlipemia during pancreatic disorders, investigations on changes of serum lipids, measurements of lipoprotein and number of chylomicra after oral administration of fat (safflower oil or olive oil) and studies on post-heparin lipoprotein lipase were done on patients with chronic pancreatitis and on dogs with experimental pancreatic disorders. The results o...
متن کاملPost-heparin plasma lipoprotein lipase and hepatic lipase in normal subjects and in patients with hypertriglyceridaemia: correlations to sex, age and various parameters of triglyceride metabolism.
1. A selective immunochemical method was used to measure post-heparin plasma lipoprotein lipase and hepatic lipase activity in eighty-two normal subjects and in twenty patients with type IIb, IV or V hypertriglyceridaemia. In twenty-six normal subjects the activity of post-heparin plasma lipases was compared with the kinetic parameters of endogenous plasma triglyceride metabolism. 2. The activi...
متن کاملInactivation of lipoprotein lipase by heparinase.
The ability of administered heparin to “clear” lipemic plasma has been adequately explained (2, 3) in that it induces the appearance in the plasma of lipoprotein lipase, an enzyme which catalyzes the hydrolysis of the triglyceride moiety of chylomicrons and &lipoproteins. This has caused a shift in emphasis from heparin to the lipase which, normally present in several tissues (4), appears to pl...
متن کاملIdentification of a heparin-binding domain in the distal carboxyl-terminal region of lipoprotein lipase by site-directed mutagenesis.
The interaction of lipoprotein lipase (LPL) with heparan sulfate proteoglycans plays an important role in the metabolism and catalytic function of the enzyme. We have used site-directed mutagenesis to replace the basic residues contained in a discontinuous charge cluster (residues Lys 321, Arg 405, Arg 407, Lys 409, Lys 415, and Lys 416) of avian LPL with asparagine. The mutant proteins were ex...
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عنوان ژورنال:
- Science
دوره 115 2996 شماره
صفحات -
تاریخ انتشار 1952